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Article

Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2009

Pan Shi, World Cameron J, Kovacs Christopher J, Berk Bradford C

Abstract excerpt

OBJECTIVE: Glucose 6-phosphate dehydrogenase (G6PD) maintains cellular NADPH levels, which are essential for cellular functions, such as vascular endothelial growth factor (VEGF)-induced angiogenesis. The molecular mechanisms regulating G6PD in angiogenesis are not fully understood. Because tyrosine phosphorylation is a key regulatory pathway for VEGF-mediated endothelial cell (EC) responses, we investigated...

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Share to CSK Tyrosine-Protein Kinase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neovascularization, Physiologic

Share to Proto-Oncogene Proteins c-akt

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Share to Vascular Endothelial Growth Factor A

Source

Identifiers

PMID: 19359662
DOI: 10.1161/ATVBAHA.109.184812

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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