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Article

Mendelian randomization study of interleukin-6 in chronic obstructive pulmonary disease.

Respiration; international review of thoracic diseases - 1 Jan 2011

van Durme Yannick M T A, Lahousse Lies, Verhamme Katia M C, Stolk Lisette, Eijgelsheim Mark, Loth Daan W, Uitterlinden Andre G, Breteler Monique M B, Joos Guy F, Hofman Albert, Stricker Bruno H C, Brusselle Guy G

Abstract excerpt

BACKGROUND: Cross-sectional studies have demonstrated that increased levels of interleukin-6 (IL6) are present in the airways and blood samples of patients with chronic obstructive pulmonary disease (COPD). OBJECTIVES: To investigate the association between IL6 and the risk of COPD using a Mendelian randomization approach. METHODS: Eight common single-nucleotide polymorphisms (SNPs) in the region of the IL6 gene...

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PMID: 21997388
DOI: 10.1159/000332336

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