Article
Uncovering the roles of PINK1 and parkin in mitophagy.
Autophagy - 1 Oct 2010
Matsuda Noriyuki, Tanaka Keiji
Abstract excerpt
Parkinson disease (PD) is the second most prevalent neurodegenerative disorder, and thus elucidation of the pathogenic mechanism and establishment of a fundamental cure is essential in terms of public welfare. Fortunately, our understanding of the pathogenesis of two types of recessive familial PDs--early-onset familial PD caused by dysfunction of the PTEN induced putative kinase 1 (PINK1) gene and autosomal...
Topics
- Autophagy
- Humans
- Mitochondria
- Mutation
- Parkinson Disease
- Parkinsonian Disorders
- Protein Kinases
- Ubiquitin-Protein Ligases