Article
The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy.
Cell death and differentiation - 1 Jun 2010
Michiorri S, Gelmetti V, Giarda E, Lombardi F, Romano F, Marongiu R, Nerini-Molteni S, Sale P, Vago R, Arena G, Torosantucci L, Cassina L, Russo M A, Dallapiccola B, Valente E M, Casari G
Abstract excerpt
Mutations in the PINK1 gene cause autosomal recessive Parkinson's disease. The PINK1 gene encodes a protein kinase that is mitochondrially cleaved to generate two mature isoforms. In addition to its protective role against mitochondrial dysfunction and apoptosis, PINK1 is also known to regulate m...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.