Article
Molecular insights into Parkinson's disease.
Progress in molecular biology and translational science - 1 Jan 2012
Rochet Jean-Christophe, Hay Bruce A, Guo Ming
Abstract excerpt
Mutations in SNCA, PINK1, parkin, and DJ-1 are associated with autosomal-dominant or autosomal-recessive forms of Parkinson's disease (PD), the second most common neurodegenerative disorder. Studies on the structural and functional properties of the corresponding gene products have provided significant insights into the molecular underpinnings of familial PD and the much more common sporadic forms of the disease....
Topics
- Animals
- Humans
- Mitochondria
- Models, Neurological
- Mutation
- Parkinson Disease
- Protein Kinases
- Protein Multimerization
- Protein Processing, Post-Translational
- Signal Transduction
- Translational Research, Biomedical