Article
KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay.
BMC cancer - 9 Apr 2009
Auner Veronika, Kriegshäuser Gernot, Tong Dan, Horvat Reinhard, Reinthaller Alexander, Mustea Alexander, Zeillinger Robert
Abstract excerpt
BACKGROUND: Mutations in the KRAS gene are one of the most frequent genetic abnormalities in ovarian carcinoma. They are of renewed interest as new epidermal growth factor receptor (EGFR)-targeted therapies are being investigated for use in ovarian carcinoma. As KRAS mutations are associated with poor response and resistance to EGFR-targeting drugs, this study was conducted to obtain more information on the...
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