Article
TP53 mutations are common in all subtypes of epithelial ovarian cancer and occur concomitantly with KRAS mutations in the mucinous type.
Experimental and molecular pathology - 1 Oct 2013
Rechsteiner Markus, Zimmermann Anne-Katrin, Wild Peter J, Caduff Rosmarie, von Teichman Adriana, Fink Daniel, Moch Holger, Noske Aurelia
Abstract excerpt
AIMS: Epithelial ovarian cancer (EOC) can be classified into four major types (serous, endometrioid, clear cell, mucinous). The prevalence of driver gene mutations in the different subtypes is controversial. High-grade serous carcinomas show frequent TP53 mutations, whereas KRAS and BRAF mutations are less common. In non-serous EOC, the relevance of these gene mutations remains to be elucidated. METHODS: We...
Topics
- Adenocarcinoma, Clear Cell
- Adenocarcinoma, Mucinous
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Endometrioid
- Carcinoma, Ovarian Epithelial
- Cystadenocarcinoma, Serous
- DNA Mutational Analysis
- Female
- Humans
- Middle Aged
- Mutation