Article
KRAS mutation testing in borderline ovarian tumors and low-grade ovarian carcinomas with a rapid, fully integrated molecular diagnostic system.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Oct 2017
Sadlecki Pawel, Antosik Paulina, Grzanka Dariusz, Grabiec Marek, Walentowicz-Sadlecka Malgorzata
Abstract excerpt
Epithelial ovarian neoplasms are a heterogeneous group of tumors, including various malignancies with distinct clinicopathologic and molecular features. Mutations in BRAF and KRAS genes are the most frequent genetic aberrations found in low-grade serous ovarian carcinomas and serous and mucinous borderline tumors. Implementation of targeted therapeutic strategies requires access to highly specific and highly...
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