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Article

Clinical performance evaluation of a sensitive, rapid low-throughput test for KRAS mutation analysis using formalin-fixed, paraffin-embedded tissue samples.

BMC cancer - 16 Feb 2017

Weyn Christine, Van Raemdonck Sofie, Dendooven Robina, Maes Vincent, Zwaenepoel Karen, Lambin Suzan, Pauwels Patrick

Abstract excerpt

BACKGROUND: Testing for KRAS mutations in metastatic colorectal cancer (mCRC) on formalin-fixed, paraffin embedded (FFPE) tumor tissue has become standard of care. Different molecular methods exist to determine hotspot KRAS mutations in exon 2, 3 and 4, but testing is often limited by the sensitivity and the speed of analysis. The aim of this retrospective study was to establish the clinical performance of the...

Topics

Colorectal Neoplasms
DNA Mutational Analysis
Formaldehyde
Humans
Limit of Detection
Mutation
Paraffin Embedding
Proto-Oncogene Proteins p21(ras)

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28201998
DOI: 10.1186/s12885-017-3112-0
PMCID: PMC5312443

Genes

KRAS
IVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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