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Article

Conserved extracellular cysteines differentially regulate the inhibitory effect of ethanol in rat P2X4 receptors.

Biochemical and biophysical research communications - 27 Mar 2009

Yi Chu-Li, Liu Yu-Wei, Xiong Ke-Ming, Stewart Randall R, Peoples Robert W, Tian Xiang, Zhou Li, Ai Yong-Xun, Li Zhi-Wang, Wang Qin-Weng, Li Chao-Ying

Abstract excerpt

Relatively little information is available about the molecular mechanism of ethanol inhibition of P2X receptors. Here, we investigated the possibility that 10 conserved cysteine residues in the extracellular loop of the rat P2X4 receptor may regulate ethanol inhibition of the receptor using a series of individual cysteine to alanine point mutations. Each of the mutated receptors generated robust inward current in...

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Identifiers

PMID: 19351603
DOI: 10.1016/j.bbrc.2009.02.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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