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Article

Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors.

The Journal of biological chemistry - 18 Jul 2008

Roberts Jonathan A, Digby Helen R, Kara Madina, El Ajouz Sam, Sutcliffe Michael J, Evans Richard J

Abstract excerpt

The agonist binding site of ATP-gated P2X receptors is distinct from other ATP-binding proteins. Mutagenesis on P2X(1) receptors of conserved residues in mammalian P2X receptors has established the paradigm that three lysine residues, as well as FT and NFR motifs, play an important role in mediat...

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Identifiers

PMID: 18487206
DOI: 10.1074/jbc.M800294200
PMCID: PMC2459275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18487206-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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