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Article

The mechanism by which ethanol inhibits rat P2X4 receptors is altered by mutation of histidine 241.

British journal of pharmacology - 1 Jul 2005

Xiong Keming, Hu Xiang-Qun, Stewart Randall R, Weight Forrest F, Li Chaoying

Abstract excerpt

1. We investigated ethanol inhibition of the rat P2X(4) receptor and the contribution of the three histidine residues in the extracellular loop of this receptor to ethanol inhibition of receptor function, using site-directed mutagenesis and electrophysiological characterization of recombinant receptors. 2. In the wild-type receptor, 50, 200 and 500 mM ethanol increasingly shifted the ATP concentration-response...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15765101
DOI: 10.1038/sj.bjp.0706192
PMCID: PMC1576171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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