Article
Possible involvement of RasGRP4 in leukemogenesis.
International journal of hematology - 1 May 2009
Watanabe-Okochi Naoko, Oki Toshihiko, Komeno Yukiko, Kato Naoko, Yuji Koichiro, Ono Ryoichi, Harada Yuka, Harada Hironori, Hayashi Yasuhide, Nakajima Hideaki, Nosaka Tetsuya, Kitaura Jiro, Kitamura Toshio
Abstract excerpt
It is now conceivable that leukemogenesis requires two types of mutations, class I and class II mutations. We previously established a mouse bone marrow-derived HF6, an IL-3-dependent cell line, that was immortalized by a class II mutation MLL/SEPT6 and can be fully transformed by class I mutations such as FLT3 mutants. To understand the molecular mechanism of leukemogenesis, particularly progression of...
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