Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development of a Multi-Step Leukemogenesis Model of MLL-Rearranged Leukemia Using Humanized Mice

20 Jun 2012

Abstract excerpt

Mixed-lineage-leukemia (MLL) fusion oncogenes are intimately involved in acute leukemia and secondary therapy-related acute leukemia. To understand MLL-rearranged leukemia, several murine models for this disease have been established. However, the mouse leukemia derived from mouse hematopoietic stem cells (HSCs) may not be fully comparable with human leukemia. Here we developed a humanized mouse model for human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to CAR-T cell therapy research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22745659
DOI: 10.1371/journal.pone.0037892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development of a Multi-Step Leukemogenesis Model of MLL-Rearranged Leukemia Using Humanized MicePMID 22745659Read ↗

Modeling the Initiation and Progression of Human Acute Leukemia in MiceSemantic proximity Read ↗

Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.Semantic proximity Read ↗

Use of human AML cells to study graft-versus-leukemia immunity in xenogeneic mouse models of GVHDSemantic proximity Read ↗

KRAS (G12D) cooperates with AML1/ETO to initiate a mouse model mimicking human acute myeloid leukemia.Semantic proximity Read ↗

MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment.Semantic proximity Read ↗

Murine Models of Acute Myeloid LeukaemiaSemantic proximity Read ↗

Mixed lineage leukemia: roles in human malignancies and potential therapySemantic proximity Read ↗

Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Semantic proximity Read ↗

The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitmentSemantic proximity Read ↗

MLL leukemia induction by genome editing of human CD34+ hematopoietic cellsSemantic proximity Read ↗

MLL/AF10(OM-LZ)-immortalized cells expressed cytokines and induced host cell proliferation in a mouse bone marrow transplantation model.Semantic proximity Read ↗

Mouse models of MLL leukemia: recapitulating the human diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.