Article
Association of transforming growth factor beta1 gene polymorphisms and asbestos-induced fibrosis and tumors.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Jun 2009
Helmig Simone, Belwe Alexandra, Schneider Joachim
Abstract excerpt
AIM: Inhaled asbestos fibers are known to cause progressive lung or pleural fibrosis and malignancies such as lung cancer or diffuse malignant mesothelioma. Transforming growth factor beta1 (TGF-beta1), a multifunctional cytokine, regulates the proliferation and differentiation of cells. Transforming growth factor beta1 is known to promote the pathogenesis of lung fibrosis and acts as a tumor suppressor in normal...
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