Article
Transforming growth factor-beta1 genotype and susceptibility to chronic obstructive pulmonary disease.
Thorax - 1 Feb 2004
Wu L, Chau J, Young R P, Pokorny V, Mills G D, Hopkins R, McLean L, Black P N
Abstract excerpt
BACKGROUND: Only a few long term smokers develop symptomatic chronic obstructive pulmonary disease (COPD) and this may be due, at least in part, to genetic susceptibility to the disease. Transforming growth factor beta1 (TGF-beta1) has a number of actions that make it a candidate for a role in the pathogenesis of COPD. We have investigated a single nucleotide polymorphism at exon 1 nucleotide position 29 (T-->C)...
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