Article
Tumour necrosis factor-alpha gene polymorphisms in asbestos-induced diseases.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Aug 2010
Helmig Simone, Aliahmadi Nahid, Schneider Joachim
Abstract excerpt
BACKGROUND: Tumour necrosis factor (TNF)-alpha influences the pathogenesis of lung fibrosis and carcinogenesis in normal cells. Polymorphisms of this gene have been suggested to be associated with susceptibility to lung diseases. METHODS: Association studies were performed in German subjects, using control subjects (n = 177), pulmonary fibrosis patients (n = 612) and bronchial carcinoma patients (n = 374)....
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