Article
The association of transforming growth factor beta 1 gene polymorphisms with the emphysema phenotype of COPD in Japanese.
Internal medicine (Tokyo, Japan) - 1 Jan 2008
Ito Michiko, Hanaoka Masayuki, Droma Yunden, Hatayama Orie, Sato Etsuro, Katsuyama Yoshihiko, Fujimoto Keisaku, Ota Masao
Abstract excerpt
OBJECTIVE: The transforming growth factor beta-1 gene (TGFB1) is one of the most promising candidate genes for chronic obstructive pulmonary disease (COPD). Several case-control studies have been performed and generated inconsistent results. The possible reasons for these discrepancies include the diversity of ethnic populations and the heterogeneity of COPD, including emphysema and airway disease. We designed...
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