Article
Transforming growth factor-beta (TGF-beta1) genotype and lung allograft fibrosis.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Jun 1999
El-Gamel A, Awad M R, Hasleton P S, Yonan N A, Hutchinson J A, Campbell C S, Rahman A H, Deiraniya A K, Sinnott P J, Hutchinson I V
Abstract excerpt
BACKGROUND: TGF-beta1 is a prosclerotic cytokine implicated in fibrotic processes. Fibrosis of the pulmonary parenchyma and airways is a frequent presentation in lung transplant recipients before and after transplantation. There are two genetic polymorphisms in the DNA sequence encoding the leader sequence of the TGF-beta1 protein, located at codon 10 (either leucine or proline) and at codon 25 (either arginine...
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