Article
Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores.
Matrix biology : journal of the International Society for Matrix Biology - 1 Jun 2020
Schnieder Jennifer, Mamazhakypov Argen, Birnhuber Anna, Wilhelm Jochen, Kwapiszewska Grazyna, Ruppert Clemens, Markart Philipp, Wujak Lukasz, Rubio Karla, Barreto Guillermo, Schaefer Liliana, Wygrecka Malgorzata
Abstract excerpt
In healing tissue, fibroblasts differentiate to α-smooth muscle actin (SMA)-expressing contractile-myofibroblasts, which pull the wound edges together ensuring proper tissue repair. Uncontrolled expansion of the myofibroblast population may, however, lead to excessive tissue scarring and finally to organ dysfunction. Here, we demonstrate that the loss of low-density lipoprotein receptor-related protein (LRP) 1...
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