Article
HLA class I and II alleles and response to treatment with interferon-beta in relapsing-remitting multiple sclerosis.
Journal of neuroimmunology - 29 May 2009
Comabella M, Fernández-Arquero M, Río J, Guinea A, Fernández M, Cenit M C, de la Concha E G, Montalban X
Abstract excerpt
In the present study, we investigated the influence of HLA class I and class II genes in the response to interferon-beta (IFNbeta) in multiple sclerosis (MS) patients. HLA-A, -B, -C, -DRB1, -DQA1, and -DQB1 DNA typing was performed by polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) in a cohort of 149 relapsing-remitting MS patients classified into IFNbeta responders (n=74) and non-responders...
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