Article
Association study of promoter polymorphisms of interferon alpha and beta receptor subunit 1 (IFNAR1) gene and therapeutic response to interferon-beta in patients with multiple sclerosis.
Molecular biology reports - 1 Aug 2021
Hajian Samin, Mazdeh Mehrdokht, Nouri Fatemeh, Roshanaei Ghodratollah, Soleimani Meysam
Abstract excerpt
BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease described by inflammatory neuronal losses and resultant failures. The disease could abate by interferon-beta (IFN-β) therapy in MS patients. However, the drug response productivity is changeable between patients, and the accurate mechanism of action of the IFN-β is not obvious. The present study aims to investigate the role of interferon alpha and beta...
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