Article
HLA class II and response to interferon-beta in multiple sclerosis.
Acta neurologica Scandinavica - 1 Dec 2005
Fernández O, Fernández V, Mayorga C, Guerrero M, León A, Tamayo J A, Alonso A, Romero F, Leyva L, Alonso A, Luque G, de Ramón E
Abstract excerpt
OBJECTIVE: To study the relationship between human leucocyte antigen (HLA) genotype and clinical response to interferon-beta (IFN-beta). METHODS: We analysed the HLA class II genotypes of 96 multiple sclerosis (MS) patients treated with IFN-beta. The patients were classified as responders or non-responders according to clinical criteria: one or more relapses or a sustained increase after 1 year treatment compared...
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