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Article

IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response.

Journal of neuroimmunology - 1 Jun 2005

Leyva Laura, Fernández Oscar, Fedetz Maria, Blanco Eva, Fernández Victoria E, Oliver Begoña, León Antonio, Pinto-Medel Maria-Jesus, Mayorga Cristobalina, Guerrero Miguel, Luque Gloria, Alcina Antonio, Matesanz Fuencisla

Abstract excerpt

We investigated the role of three polymorphisms in the IFNAR1 (SNPs 18417 and -408) and IFNAR2 (SNP 11876) genes in multiple sclerosis (MS) susceptibility and in the IFNbeta treatment response in a group of 147 patients and 210 controls undergoing interferon therapy during the last 2 years. Only the 18417 and the 11876 SNPs showed an association with disease susceptibility (p=0.001 and 0.035, respectively)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15885318
DOI: 10.1016/j.jneuroim.2005.02.010

Genes

IFNAR1
IFNAR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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