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Article

Phenotypic characterization of mice heterozygous for a null mutation of glutamate carboxypeptidase II.

Synapse (New York, N.Y.) - 1 Aug 2009

Han Liqun, Picker Jonathan D, Schaevitz Laura R, Tsai Guochuan, Feng Jiamin, Jiang Zhichun, Chu Hillary C, Basu Alo C, Berger-Sweeney Joanne, Coyle Joseph T

Abstract excerpt

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. Disturbed glutamate signaling resulting in hypofunction of N-methyl-D-aspartate receptors (NMDAR) has been implicated in the pathophysiology of schizophrenia. Glutamate Carboxypeptidase II (GCP II) hydrolyzes N-acetyl-alpha L-aspartyl-L-glutamate (NAAG) into glutamate and N-acetyl-aspartate. NAAG is a neuropeptide that is...

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Identifiers

PMID: 19347959
DOI: 10.1002/syn.20649
PMCID: PMC2749286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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