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Article

Divergence of structure and function in the haloacid dehalogenase enzyme superfamily: Bacteroides thetaiotaomicron BT2127 is an inorganic pyrophosphatase.

Biochemistry - 18 Oct 2011

Huang Hua, Patskovsky Yury, Toro Rafael, Farelli Jeremiah D, Pandya Chetanya, Almo Steven C, Allen Karen N, Dunaway-Mariano Debra

Abstract excerpt

The explosion of protein sequence information requires that current strategies for function assignment evolve to complement experimental approaches with computationally based function prediction. This necessitates the development of strategies based on the identification of sequence markers in the form of specificity determinants and a more informed definition of orthologues. Herein, we have undertaken the...

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PMID: 21894910
DOI: 10.1021/bi201181q
PMCID: PMC3342813

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