Article
Effects of global or targeted deletion of the EP4 receptor on the response of osteoblasts to prostaglandin in vitro and on bone histomorphometry in aged mice.
Bone - 1 Jul 2009
Gao Qi, Zhan Peili, Alander Cynthia B, Kream Barbara E, Hao Chuanming, Breyer Matthew D, Pilbeam Carol C, Raisz Lawrence G
Abstract excerpt
Because global deletion of the prostaglandin EP4 receptor results in neonatal lethality, we generated a mouse with targeted EP4 receptor deletion using Cre-LoxP methodology and a 2.3 kb collagen I a1 promoter driving Cre recombinase that is selective for osteoblastic cells. We compared wild type (WT), global heterozygote (G-HET), targeted heterozygote (T-HET) and knockout (KO) mice. KO mice had one targeted and...
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