Article
Mitochondrial DNA sequence variation in Finnish patients with matrilineal diabetes mellitus.
BMC research notes - 10 Jul 2012
Soini Heidi K, Moilanen Jukka S, Finnila Saara, Majamaa Kari
Abstract excerpt
BACKGROUND: The genetic background of type 2 diabetes is complex involving contribution by both nuclear and mitochondrial genes. There is an excess of maternal inheritance in patients with type 2 diabetes and, furthermore, diabetes is a common symptom in patients with mutations in mitochondrial DNA (mtDNA). Polymorphisms in mtDNA have been reported to act as risk factors in several complex diseases. FINDINGS: We...
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