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Article

Likely role of APOBEC3G-mediated G-to-A mutations in HIV-1 evolution and drug resistance.

PLoS pathogens - 1 Apr 2009

Jern Patric, Russell Rebecca A, Pathak Vinay K, Coffin John M

Abstract excerpt

The role of APOBEC3 (A3) protein family members in inhibiting retrovirus infection and mobile element retrotransposition is well established. However, the evolutionary effects these restriction factors may have had on active retroviruses such as HIV-1 are less well understood. An HIV-1 variant that has been highly G-to-A mutated is unlikely to be transmitted due to accumulation of deleterious mutations. However,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19343218
DOI: 10.1371/journal.ppat.1000367
PMCID: PMC2659435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Likely role of APOBEC3G-mediated G-to-A mutations in HIV-1 evolution and drug resistance.PMID 19343218Read ↗

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