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Article

The Disassociation of A3G-Related HIV-1 cDNA G-to-A Hypermutation to Viral Infectivity.

Viruses - 4 May 2024

Martin Joanie, Chen Xin, Jia Xiangxu, Shao Qiujia, Liu Bindong

Abstract excerpt

APOBEC3G (A3G) restricts HIV-1 replication primarily by reducing viral cDNA and inducing G-to-A hypermutations in viral cDNA. HIV-1 encodes virion infectivity factor (Vif) to counteract A3G primarily by excluding A3G viral encapsidation. Even though the Vif-induced exclusion is robust, studies suggest that A3G is still detectable in the virion. The impact of encapsidated A3G in the HIV-1 replication is unclear....

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Share to APOBEC-3G Deaminase
Share to DNA, Complementary
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to vif Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 38793610
DOI: 10.3390/v16050728
PMCID: PMC11126051

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Disassociation of A3G-Related HIV-1 cDNA G-to-A Hypermutation to Viral Infectivity.PMID 38793610Read ↗

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