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Article

Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6.

Cell cycle (Georgetown, Tex.) - 1 May 2009

Gao Wenda, Thompson Lorraine, Zhou Qiang, Putheti Prabhakar, Fahmy Tarek M, Strom Terry B, Metcalfe Su M

Abstract excerpt

Within the immune system there is an exquisite ability to discriminate between "self" and "non-self" that is orchestrated by T lymphocytes. Discriminatory pathways guide differentiation of these lymphocytes into either regulatory (Treg) or effector (Teff) T cells, influenced by cues from the naïve T cell's immediate micro-environment as it responds to cognate antigen. Reciprocal pathways may lead to commitment of...

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Identifiers

PMID: 19342884
DOI: 10.4161/cc.8.9.8348
PMCID: PMC2881570

Genes

LIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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