Article
Characterization of mutant HA-ras gene expression in transformed murine keratinocyte lines grown under in vitro and in vivo conditions.
Molecular carcinogenesis - 1 Dec 1996
Volpe J P, Conti C J, Slaga T J
Abstract excerpt
We investigated the Ha-ras and Ki-ras gene status, tumorigenicity, pathology, line derivation, and intercellular communication of 7,12-dimethylbenz[a]anthracene-initiated papilloma-, carcinoma-, and hyperplastic skin-producing cell lines to further characterize them. Six of nine tumor cell lines grown in vitro expressed both mutant and normal Ha-ras proteins, and three lines expressed only normal Ha-ras. However,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
