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Article

Gastric acid secretion in cyclooxygenase-1 deficient mice.

Alimentary pharmacology & therapeutics - 1 Oct 2000

Borrelli F, Welsh N J, Sigthorsson G, Simpson R, Palizban A, Bjarnason I, Tavares I A

Abstract excerpt

BACKGROUND: Constitutive cyclooxygenase-1 enzyme synthesizes prostaglandins which are thought to play an important role in the functional integrity of the stomach gastric mucosa. Recently, it was shown that cyclooxygenase-1 deficient mutant mice did not develop spontaneous gastric pathology and appear less sensitive to indomethacin-induced gastric damage. AIM: To investigate gastric acid secretion in...

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PMID: 11012484
DOI: 10.1046/j.1365-2036.2000.00836.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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