Article
Gastric phenotypic abnormality in cholecystokinin 2 receptor null mice.
Pharmacology & toxicology - 1 Dec 2002
Chen Duan, Zhao Chun-Mei, Håkanson Rolf, Rehfeld Jens F
Abstract excerpt
Gastrin, released from antral G-cells, plays an important role in the regulation of gastric acid secretion and is trophic for the stomach. The cholecystokinin type 2 (CCK)2 receptor (previously referred to as CCK-B/gastrin receptors) is expressed in both parietal cells and ECL cells in the oxyntic mucosa of stomach. Gastric phenotypic abnormality has been observed in CCK2 receptor null (gene knock-out) mice. Such...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
