Article
Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome.
Human molecular genetics - 1 Aug 2005
Nuber Ulrike A, Kriaucionis Skirmantas, Roloff Tim C, Guy Jacky, Selfridge Jim, Steinhoff Christine, Schulz Ralph, Lipkowitz Bettina, Ropers H Hilger, Holmes Megan C, Bird Adrian
Abstract excerpt
Rett syndrome (RTT) is a severe form of mental retardation, which is caused by spontaneous mutations in the X-linked gene MECP2. How the loss of MeCP2 function leads to RTT is currently unknown. Mice lacking the Mecp2 gene initially show normal postnatal development but later acquire neurological phenotypes, including heightened anxiety, that resemble RTT. The MECP2 gene encodes a methyl-CpG-binding protein that...
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