Article
Genome instability in secondary solid tumors developing after radiotherapy of bilateral retinoblastoma.
Oncogene - 6 Dec 2001
Lefèvre S H, Vogt N, Dutrillaux A M, Chauveinc L, Stoppa-Lyonnet D, Doz F, Desjardins L, Dutrillaux B, Chevillard S, Malfoy B
Abstract excerpt
Genome alterations of seven secondary tumors (five osteosarcomas, one malignant peripheral sheath nerve tumor, one leiomyosarcoma) occurring in the field of irradiation of patients treated for bilateral retinoblastoma have been studied. These patients were predisposed to develop radiation-induced tumors because of the presence of a germ line mutation in the retinoblastoma gene (RB1). Tumor cells were...
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