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Article

High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer.

Cancer research - 15 Apr 2009

Holstege Henne, Joosse Simon A, van Oostrom Conny Th M, Nederlof Petra M, de Vries Annemieke, Jonkers Jos

Abstract excerpt

Approximately half of all hereditary breast cancers are compromised in their DNA repair mechanisms due to loss of BRCA1 or BRCA2 function. Previous research has found a strong correlation between BRCA mutation and TP53 mutation. However, TP53 mutation status is often indirectly assessed by immuno...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19336573
DOI: 10.1158/0008-5472.CAN-08-3426

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19336573-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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