Article
Early onset HER2-positive breast cancer is associated with germline TP53 mutations.
Cancer - 15 Feb 2012
Melhem-Bertrandt Amal, Bojadzieva Jasmina, Ready Kaylene J, Obeid Elias, Liu Diane D, Gutierrez-Barrera Angelica M, Litton Jennifer K, Olopade Olufunmilayo I, Hortobagyi Gabriel N, Strong Louise C, Arun Banu K
Abstract excerpt
BACKGROUND: Germline TP53 mutations predispose to early onset breast cancer in women and are associated with Li-Fraumeni syndrome. Published data on the pathological characteristics of breast cancer among women with TP53 mutations is limited. METHODS: We retrospectively reviewed the clinical records of women who underwent genetic testing for suspected germline TP53 mutations and who were diagnosed with breast...
Topics
- Adult
- Aged
- Aging
- Biomarkers, Tumor
- Breast Neoplasms
- Case-Control Studies
- Female
- Genetic Predisposition to Disease
- Genetic Testing
- Germ-Line Mutation
- Humans
- Middle Aged
- Receptor, ErbB-2