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Article

Association between Folate Levels and CpG Island Hypermethylation in Normal Colorectal Mucosa

1 Dec 2010

Abstract excerpt

Gene-specific promoter methylation of several genes occurs in aging normal tissues and may predispose to tumorigenesis. In the present study, we investigate the association of blood folate levels and dietary and lifestyle factors with CpG island (CGI) methylation in normal colorectal mucosa. Subjects were enrolled in a multicenter chemoprevention trial of aspirin or folic acid for the prevention of large bowel...

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PMID: 21149331
DOI: 10.1158/1940-6207.capr-10-0047

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