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Article

Phosphorylated 4E-BP1 is associated with poor survival in melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2009

O'Reilly Kathryn E, Warycha Melanie, Davies Michael A, Rodrik Vanessa, Zhou Xi K, Yee Herman, Polsky David, Pavlick Anna C, Rosen Neal, Bhardwaj Nina, Mills Gordon, Osman Iman

Abstract excerpt

PURPOSE: Both phosphatidylinositol 3-kinase/AKT and RAS/mitogen-activated protein kinase signal transduction pathways mediate 4E-BP1 phosphorylation, releasing 4E-BP1 from the mRNA cap and permitting translation initiation. Given the prevalence of PTEN and BRAF mutations in melanoma, we first examined translation initiation, as measured by phosphorylated 4E-BP1 (p-4E-BP1), in metastatic melanoma tissues and cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 19336517
DOI: 10.1158/1078-0432.CCR-08-2336
PMCID: PMC3995540

Genes

PTEN
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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