Article

The Downregulation of EIF3a Contributes to Vemurafenib Resistance in Melanoma By Activating ERK Via PPP2R1B

2021-05-17

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Vemurafenib, a BRAF V600E inhibitor, provides therapeutic benefits for melanoma patients, but the frequently emergence of drug resistance remains a challenge. Understanding the mechanisms behind vemurafenib resistance may generate novel therapeutic strategy for melanoma patients. <bold>Methods: </bold>KEGG analysis for eIF3a-mediated pathway and identified the K...

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Literature Corpus work: 31b28fca-3242-545a-b8c0-a13ca53b6ff8
DOI: 10.21203/rs.3.rs-498841/v1

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