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Article

Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1

14 Dec 2017

Abstract excerpt

Loss of 4E-BP1 expression has been linked to cancer progression and resistance to mTOR inhibitors, but the mechanism underlying 4E-BP1 downregulation in tumors remains unclear. Here we identify Snail as a strong transcriptional repressor of 4E-BP1. We find that 4E-BP1 expression inversely correlates with Snail level in cancer cell lines and clinical specimens. Snail binds to three E-boxes present in the human...

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PMID: 29263324
DOI: 10.1038/s41467-017-02243-3

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