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Article

Precise gene-dose alleles for chemical genetics.

Genetics - 1 Jun 2009

Yan Zhun, Berbenetz Nicolas M, Giaever Guri, Nislow Corey

Abstract excerpt

Modulating gene dose is an effective way to alter protein levels and modify phenotypes to understand gene function. In addition, combining gene-dose alleles with chemical perturbation can provide insight into drug-gene interactions. Here, we present a strategy that combines diverse loss-of-function alleles to systematically modulate gene dose in Saccharomyces cerevisiae. The generated gene dosage allele set...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19332878
DOI: 10.1534/genetics.109.103036
PMCID: PMC2691769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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