Article
Genomic profiling of drug sensitivities via induced haploinsufficiency.
Nature genetics - 1 Mar 1999
Giaever G, Shoemaker D D, Jones T W, Liang H, Winzeler E A, Astromoff A, Davis R W
Abstract excerpt
Lowering the dosage of a single gene from two copies to one copy in diploid yeast results in a heterozygote that is sensitized to any drug that acts on the product of this gene. This haploinsufficient phenotype thereby identifies the gene product of the heterozygous locus as the likely drug target. We exploited this finding in a genomic approach to drug-target identification. Genome sequence information was used...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.