Advances in chemical genetics.

doi:10.1146/annurev.genom.6.080604.162136

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Article

Advances in chemical genetics.

Annual review of genomics and human genetics - 1 Jan 2005

Smukste Inese, Stockwell Brent R

Abstract excerpt

Chemical genetics is an emerging approach for studying biological systems using chemical tools. This strategy aims to reveal the macromolecules responsible for regulating biological systems; thus, the approach shares much in common with genetics. In both strategies, one must (a) develop an assay that reports on a biological process of interest, (b) perturb this process systematically (with mutations or small...

Topics

Combinatorial Chemistry Techniques
Gene Library
Ligands
Macromolecular Substances
Molecular Biology
Peptide Library
Phenotype

Source

Open in PubMed

Identifiers

PMID: 16124862
DOI: 10.1146/annurev.genom.6.080604.162136

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