Article
An HLA-A3-binding prostate acid phosphatase-derived peptide can induce CTLs restricted to HLA-A2 and -A24 alleles.
Cancer immunology, immunotherapy : CII - 1 Nov 2009
Terasaki Yasunobu, Shichijo Shigeki, Niu Yamei, Komatsu Nobukazu, Noguchi Masanori, Todo Satoru, Itoh Kyogo
Abstract excerpt
We previously reported peptide vaccine candidates for HLA-A3 supertype (-A3, -A11, -A31, -A33)-positive cancer patients. In the present study, we examined whether those peptides can also induce cytotoxic T lymphocyte (CTL) activity restricted to HLA-A2, HLA-A24, and HLA-A26 alleles. Fourteen peptides were screened for their binding activity to HLA-A*0201, -A*0206, -A*0207, -A*2402, and -A*2601 molecules and then...
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