Article
Identification of HLA-DRB1*1501-restricted T-cell epitopes from human prostatic acid phosphatase.
The Prostate - 1 Jul 2007
Klyushnenkova Elena N, Kouiavskaia Diana V, Kodak James A, Vandenbark Arthur A, Alexander Richard B
Abstract excerpt
BACKGROUND: The crucial role of CD4 T-cells in anti-tumor immune response is widely recognized, yet the identification of HLA class II-restricted epitopes derived from tumor antigens has lagged behind compared to class I epitopes. This is particularly true for prostate cancer. Based on the hypothesis that successful cancer immunotherapy will likely resemble autoimmunity, we searched for the CD4 T-cell epitopes...
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