Article
New peptide vaccine candidates for epithelial cancer patients with HLA-A3 supertype alleles.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Apr 2007
Matsueda Satoko, Takedatsu Hiroko, Sasada Tetsuro, Azuma Koichi, Ishihara Yuki, Komohara Yoshihiro, Noguchi Masanori, Shichijo Shigeki, Itoh Kyogo, Harada Mamoru
Abstract excerpt
We previously identified 2 cancer-associated antigens, immediate early response gene X-1 (IEX) and small GTPase (Ran), and their 5 epitopes using human leukocyte antigen (HLA)-A33-restricted and tumor-infiltrating T cells from a colon cancer patient. In this study, we examined whether or not these peptides can induce cytotoxic T lymphocytes (CTLs) in HLA-A11+ or HLA-A31+ epithelial cancer patients because the...
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