Article
Identification of MHC class II-restricted T-cell epitopes in prostate-specific membrane antigen.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2003
Schroers Roland, Shen Lei, Rollins Lisa, Xiao Zhen, Sonderstrup Grete, Slawin Kevin, Huang Xue F, Chen Si-Yi
Abstract excerpt
An effective tumor vaccine may be required to induce both CTLs and T-helper (Th) responses against tumor-associated antigens. CD4+ Th cells that recognize MHC class II-restricted epitopes play a central role in the initiation and maintenance of antitumor immune responses. Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer and thus is a potential target for prostate cancer...
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