Article
Identification of peptide vaccine candidates for prostate cancer patients with HLA-A3 supertype alleles.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2005
Matsueda Satoko, Takedatsu Hiroko, Yao Akihisa, Tanaka Masahiro, Noguchi Masanori, Itoh Kyogo, Harada Mamoru
Abstract excerpt
PURPOSE: The peptide vaccine candidates identified to date have been focused on the HLA-A2 and HLA-A24 alleles. The HLA-A11, HLA-A31, and HLA-A33 alleles share binding motifs and belong to an HLA-A3 supertype family. In this study, we attempted to identify CTL-directed peptide candidates, derived from prostate-related antigens and shared by HLA-A11+, HLA-A31+, and HLA-A33+ prostate cancer patients. EXPERIMENTAL...
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